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KMID : 0355619960220040561
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Journal of Korean Association of Oral and Maxillofacial Surgeons
1996 Volume.22 No. 4 p.561 ~ p.574
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Effect of resorbable, non-resorbable, and bovine-derived hydroxyapatite on the repair of experimental bone defects in dogs
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Abstract
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The purpose of this study was to investigate the effects of resorbable, non-resorbable and bovine-derived hydroxyapatite(HA) on the repair of experimental bone defects.
Six mongrel dogs, weighing 15kg, were used. Four surgical bone defects sized 1cm* were created at the iliac bone under general anesthesia. In control group, the defect was filled with blood clot : in resorbable HA group, filled with resorbable
HA:
in
non-resorbable HA group, filled with non-resorbable HA: and in bovine-derived HA group, filled with bovine-derived HA. The animals were sacrificed at 1, 2, 4, 8 and 12 weeks after the graft. Tissue specimens were obtained for radiographic and
light
microscopic examination.
@ES Results obtained were as follows:
@EN 1. Macroscopically, neither infection of the graft site nor dislodgement of the grafted material was noted.
2. In the examination of radiographic density, gray level of all of the HA groups was higher than that of the control group. The gray level increased in all groups with time, but the rate of increase was slowered in the non-resorbable HA group.
3. In the resorbable HA group. woven bone was formed from surrounding host bone through osteocondurction at 1 week after the graft. The bone defect was healed with bone trabeculae at 4 weeks and with mature bone at 8 weeks after the graft.
4. In the non-resorbable HA group, healing process was slower than that in the resorbable HA group and unresorbed HA particles were observed at 12 weeks after the graft.
5. In the bovine-derived HA group, bone trabeculae were formed through interconnection of woven bone matrix and the lamellar structure was seen in the 8 weeks after the graft.
6. In all HA groups, new bone formation was more rapid than that in the control group. There were no significant differences in the capability of bone formation among the three HA groups, where new bone was formed by osteoconduction.
These results suggest that resorbable, non-resorbable, and bovine-derived hydroxyapatite can be used as bone substitutes to promote new bone formation in the bone defect.
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